Scientist I/II, Genomics and Molecular Biology – Flagship Pioneering, Inc.

Company Summary:

Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

Position Summary:

The RNA Rewriting group is seeking a Scientist to support the molecular characterization of novel gene writers to advance candidate selection efforts. We are looking for a highly independent, enthusiastic, and self-motivated individual to work on various aspects of the gene writers’ characterization. This individual will join a dynamic, collaborative and rapidly growing team.

Key Responsibilities:

• Develop and lead new projects, experiments, scientific processes to support characterization of novel rewriters.
• Actively undertake technology development efforts in the gene editing space.
• Keep up with advances in genomics and genome engineering and strategize on prioritizing and onboarding cutting-edge technologies to advance R&D efforts.

Basic Qualifications

• Deep understanding of and experience in carrying out on and off-target characterization in the CRISPR-Cas9 context.
• Expertise in characterizing DNA and RNA binding proteins, including use of ChIP/RIP-Seq.
• Experience in building out NGS pipelines: Illumina based DNA and RNA library construction, QC using TapeStation and fragment analyzer, running a MiSeq/ NextSeq.
• Extensive experience in mammalian cell culture of primary and cancer cell lines (U2OS, HEK293, etc.).
• Experience in independently developing and leading projects.
• Ability to work in a cross-functional, multi-disciplinary environment and in an agile and highly collaborative fashion.
• Strong attention to detail with respect to executing experiments and record-keeping and experience with electronic lab notebook maintenance.

Preferred Experience (not required):

• Experience with mouse/ human primary hepatocytes, iPSCs, 3D cell culture
• Experience with long read sequencing technologies
• Experience with liquid handling and automated NGS pipelines

Education and relevant work experience:

• Ph.D. in biological sciences. Title commensurate with experience.

More About Flagship Pioneering

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $50B in aggregate value. To date, Flagship has deployed over $2.2B in capital toward the founding and growth of its pioneering companies alongside more than $18B of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO), Foghorn Therapeutics (NASDAQ: FHTX), Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Sigilon Therapeutics (NASDAQ: SGTX).

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.